Kasyanenko Nina A.

Kasyanenko Nina A.

D.Sc., Professor

Email: n.kasyanenko@spbu.ru

  • Conformational and phase transitions of DNA during interaction with a biologically active compounds, supramolecular structures based on the Nucleic Acids

    • DNA complexes with biologically active compounds
    • Gene vectors based on interpolyelectrolyte complexes
    • DNA-based nanostructures
    • DNA-peptide interaction

    Funding (current):

    RFBR, SPbSU, Grant for staff support of scientific research conducted under the direction of St. Petersburg State University leading scientists

    Main publications

    1. Model system for multifunctional delivery nanoplatforms based on DNA-polymer complexes containing silver nanoparticles and fluorescent dye. Kasyanenko N., Bakulev V., Perevyazko I., Nekrasova T., Nazarova O., Slita A., Zolotova Yu., Panarin E. / Journal of Biotechnology. 2016.Volume 236, Pages 78–87. Doi: 10.1016/j.jbiotec.2016.08.010
    2. Similarities and differences in the influence of polycations and oligomers on DNA conformation and packaging. Kasyanenko N., Dribinsky B. / International Journal of Biological Macromolecules. 2016. Том: 86,   Стр.: 216-223 DOI: 10.1016/j.ijbiomac.2016.01.044
    3. DNA modified with metal nanoparticles: preparation and characterization of ordered metal-dna nanostructures in a solution and on a substrate. Kasyanenko N., Varshavskii M., Ikonnikov E., Tolstyko E., Belykh R., Sokolov P., Bakulev V., Rolich V., Lopatko K. / Journal of Nanomaterials. V. 2016, 3237250.  Doi: 10.1155/2016/3237250
    4. Tetrapeptide KEDW interacts with dna and regulates gene expression. Khavinson V.Kh, Tendler S.M., Kasyanenko N.A., Tarnovskaya S.I., Linkova N.S., Ashapkin V.V., Yakutseni P.P., Vanyushin B.F. /American journal of biomedical sciences, изд. New World Publishing International (Sarasota, Fla., United States), том 7, № 3, с. 156-169.
    5. Conformational and phase transitions in DNA – photosensitive surfactant solutions: experiment and modeling. Kasyanenko N., Lysyakova L., Ramazanov R., Titov E., Alexeev G., Lezov A., Unksov I., Nesterenko A., Yaroshevich I. /Biopolymers. 2015. Т. 103. № 2. С. 109-122.
    6. Adsorption of 1,10-phenanthroline-2,9-dithiol on gold and silicon surfaces. Sokolov P., Kasyanenko N., Demidov V., Vedeneeva L. /Journal of Physical Chemistry C. 2015. Т. 119. № 43. С. 24358-24363.
    7. Peptide regulation of gene expression and protein synthesis in bronchial epithelium. Tendler S.M., Khavinson V.Kh., Vanyushin B.F., Ashapkin V.V., Kasyanenko N.A., Kvetnoy I.M., Linkova N.S., Polyakova V.O., Basharina V.S., Bernadotte A .Lung. 2014. Т. 192. № 5. С. 781-791.
    8. Properties of multicomponent system DNA-phtalocyanine metallocomplexes-surfactants. Alekseev G., Kasyanenko N. /Journal of Physics: Conference Series. 2014. Т. 572. № 1. С. 012011.
    9. DNA interaction with cis- and trans- isomers of photosensitive surfactant. Unksov I.N., Kasyanenko N.A. Journal of Physics: Conference Series. 2014. Т. 572. № 1. С. 012014.
    10. Charge-controlled fixation of DNA molecules on silicon surface and electro-physical properties of Au-DNA-Si interface. Bazlov N.V., Vyvenko O.F., Sokolov P.A., Kas’yanenko N.A., Petrov Y.V. /Applied Surface Science. 2013. Т. 267. С. 224-228.
    11. Fluorescent silver nanoclusters in condensed DNA. Volkov I.L., Ramazanov R.R., Ubyivovk E.V., Rolich V.I., Kononov A.I., Kasyanenko N.A. /Chemphyschem : a European journal of chemical physics and physical chemistry. 2013. Т. 14. № 15. С. 3543-3550.
    12. Reaction with DNA and pharmacologic activity of 1,10-phenanthroline and electron-rich 1,10-phenanthrocyanine complexes of d-elements. Demidov V.N., Antonov V.S., Pakhomova T.B., Simanova S.A., Kas’yanenko N.A., Volkov I.L., Sokolov P.A. /Russian Journal of General Chemistry. 2012. Т. 82. № 3. С. 602-620.
    13. DNA-polymer complexes for gene therapy. Kasyanenko N.A., Lysyakova L.A., Dribinskii B.A., Zolotova Yu.I., Nazarova O.V., Panarin E.F. /Polymer Science. Series C. 2012. Т. 54. № 1. С. 57-68.
    14. Metallization of DNA on silicon surface Puchkova A.O., Sokolov P., Kasyanenko N.A., Petrov Y.V. / Journal of Nanoparticle Research. 2011. Т. 13. № 9. С. 3633-3641.
    15. Investigation of the radioprotective properties of some tea polyphenols Ershov D.S., Paston S.V., Kasyanenko N.A., Kartsova L.A., Alekseeva A.V., Ganzha O.V. Structural Chemistry. 2011. Т. 22. № 2. С. 475-482.
    16. Metallization of DNA on the surface. Puchkova A.O., Sokolov P.A., Kasyanenko N.A. Journal of Structural Chemistry. 2011. Т. 52. № 6. С. 1195-1201
    17. Effect of the oligopeptide length on the DNA condensation process in aqueous-salt solutions. Dribinskii B.A., Kasyanenko N.A. Journal of Structural Chemistry. 2011. Т. 52. № 6. С. 1202-1208.
    18. DNA compaction by azobenzene-containing surfactant Zakrevskyy Y., Kopyshev A., Lomadze N., Santer S., Morozova E., Lysyakova L., Kasyanenko N. /Physical Review E – Statistical, Nonlinear, and Soft Matter Physics. 2011. Т. 84. № 2. С. 021909.
    19. DNA immobilization on n-type silicon surface and electrophysical properties of Au-DNA-(n-Si) structures. Sokolov P.A., Bazlov N.V., Puchkova A.O., Vyvenko O.F., Kasyanenko N.A. Protection of Metals and Physical Chemistry of Surfaces. 2011. Т. 47. № 5. С. 566-571
    20. Light-induced noncovalent fixation of DNA and synthetic polyions on the surface of silicon single crystals. Volkov I.L., Bazlov N.V., Bondarenko A.S., Vyvenko O.F., Kas’yanenko N.A. /Journal of Structural Chemistry. 2010. Т. 50. № 5. С. 962-969.
    21. Effects of palladium acido complexes [Ln]M[PdX4] on the conformation of DNA in vitro. Kas’yanenko N.A., Levykina E.V., Erofeeva O.S., Ivanova N.A., Efimenko I.A. Journal of Structural Chemistry. 2010. Т. 50. № 5. С. 996-1006.
    22.  Conformational changes of a DNA molecule induced by metal complexes formed in solution Kasyanenko N.A., Mukhin D.A., Perevyazko I.Yu. Polymer Science. Series C. 2010. Т. 52. № 1. С. 122-133.
    23. First ruthenium organometallic complex of antibacterial agent ofloxacin. Crystal structure and interactions with DNA. Turel I., Kljun J., Perdih F., Morozova E., Bakulev V., Kasyanenko N., Byl J.A.W., Osheroff N. /Inorganic Chemistry. 2010. Т. 49. № 23. С. 10750-10752.
    24.  Optical properties and orientational order of deoxyribonucleic acid molecules at interfaces. Grishchenko A.E., Kononov A.I., Naumova L.B., Dribinskii B.A., KasYanenko N.A./Polymer Science. Series A. 2010. Т. 52. № 1. С. 49-54.
    25.  Influence of divalent metal ions on DNA conformational transitions in water-ethanol solution. Kasyanenko, N. A.; Perevyazko, I. Y.; Blokova, M. I.; Zyryanova, R. M. Biophysics 2008, 53, (2), 229-234
    26. DNA complexes with polycations useful for delivery of DNA into cells. Kasyanenko N.A., Zakharova N.B., Mukhin D.A., Slita A.V., Nazarova O.V., Leonteva E.A., Panarin E.F. Biophysics. 2008. Т. 53. № 1. С. 31-37.
    27. Electrophoretic determination of catechins and examination of their complexing with organic and inorganic compounds. Kartsova L.A., KasYanenko N.A., Alekseeva A.V., Ganzha O.V., Paston S.V., Ershov D.S. Russian Journal of Applied Chemistry. 2008. Т. 81. № 10. С. 1758-1763.
    28. Destabilization and stabilization of poly(a) • poly(u) structure by platinum(ii) compounds. Bogdanov A.A., Kasyanenko N.A., Ivanov Yu.V., Surzhik M.A., Timkovskii A.L., Potekhin S.A., Feofanov S.A., Khusainova R.S., Yakoblev K.I. /Biophysics. 2008. Т. 53. № 5. С. 341-343.
    29. DNA self-assembling nanostructures induced by trivalent ions and polycations Kasyanenko N., Afanasieva D. NATO Science for Peace and Security Series C: Environmental Security. 2008. С. 29-38.
    30. DNA-polycation complexes effect of polycation structure on physico-chemical and biological properties. Slita A.V., Eropkina E.M., Sirotkin A.K., Smirnova T.D., Kiselev O.I., Kasyanenko N.A., Nazarova O.V., Gavrilova I.I., Panarin E.F. /Journal of Biotechnology. 2007. Т. 127. № 4. С. 679-693.
    31. DNA interaction with synthetic polymers in solution. Kasyanenko N., Afanasieva D., Dribinsky B., Mukhin D., Nazarova O., Panarin E. Structural Chemistry. 2007. Т. 18. № 4. С. 519-525.
    32. DNA packaging in water solutions induced by polylysine and spermidine. Kasyanenko N.A., Dribinskii B.A./ Journal of Structural Chemistry. 2007. Т. 48. № 4. С. 729-733.
    33. Conformational changes of DNA molecules in interactions with bioactive compounds. I. Influence of metal ions on the conformation of DNA molecules in solution. Kas’yanenko N.A. Journal of Structural Chemistry. 2006. Т. 47. № 1. С. 163-169
    34. Conformational changes of DNA molecules in interactions with bioactive compounds. II. DNA complexes with coordination compounds of cobalt and ruthenium. Kasyanenko N.A., Afanasieva D.A. /Journal of Structural Chemistry. 2006. Т. 47. № 1. С. 170-177.
    35. Peculiarities of interactions between the DNA molecule and different isomers and modifications of binuclear coordination compounds of platinum(II) Bogdanov A.A., Kosmotynskaya Yu.V., Kasyanenko N.A., Yakovlev K.I. Journal of Structural Chemistry. 2006. Т. 47. № 1. С. 178-185.
    36. Effect of dimethyl sulfoxide on DNA conformation in solution. Kosmotynskaya Yu.V., Bogdanov A.A., Kas’yanenko N.A. /Russian Journal of Physical Chemistry A. 2005. Т. 79. № S.1.
    37. Study of DNA complexation with platinum coordination compounds Kasyanenko N.A., Bogdanov A.A., Kononov A.I., Kosmotynskaya Yu.V., Abramchuk S.S., Blagodatskikh I.V., Sitnikova N.L., Khokhlov A.R. A.R., Gallyamov M.O. /Polymer Science. Series A. 2003. Т. 45. № 10. С. 960-968.
    38. Comparison of DNA complexation with antitumor agent cis-DDP and binuclear bivalent platinum compound containing pyrazine Kasyanenko N.A., Aia E.E.F., Bogdanov A.A. Molecular Biology. 2002. Т. 36. Issue 4, pp 594–600
    39.  Complexes of DNA with trivalent metal ions in presence of manganese ions Kas’ianenko N.A., Plotnikova L.V., Zanina A.V., Anderzhanov A.S., Defrenne S. Биофизика. 2002. Т. 47. № 3. С. 433-437.
    40. Interactions of a DNA molecule with coordination compounds of platinum and cobalt in solutions Kas’ianenko N.A., Bogdanov A.A., Defrenne C. Биофизика. 2002. Т. 47. № 3. С. 449-452.
    41. DNA molecule complexes with polyallylamine in solution. Kas’yanenko N.A., Obukhova O.N., Nazarova O.V., Panarin E.F. Russian Journal of Physical Chemistry A. 2002. Т. 76. № 11. С. 1837-1842.
    42. DNA complexes with divalent platinum compounds in the presence of dimethylsulfoxide Russian Journal of Physical Chemistry A. 2002. Т. 76. № 11. С. 1843-1848.  Версии: Журнал физической химии. 2002. Т. 76. С. 2043.
    43. Interaction of protonated DNA with trans-dichlorodiammineplatinum(II). Kasyanenko N.A., Prokhorova S.A., Haya Enriquez E.F., Sudakova S.S., Frisman E.V., Dyachenko S.A., Smorygo N.A., Ivin B.A. /Colloids and Surfaces A: Physicochemical and Engineering Aspects. 1999. Т. 148. № 1-2. С. 121-128.
    44. DNA interaction with complex ions in solution. Kasyanenko N.A., Zanina A.V., Nazarova O.V., Panarin E.F. /Langmuir : the ACS journal of surfaces and colloids. 1999. Т. 15. № 23. С. 7912-7917.
    45. Study of the DNA packing caused by multivalent ions Kasyanenko N. A., Nazarova O., Panarin E., Zanina A.. In: Polyelectrolytes. Ed. Ichiro Noda, Etsuo Kokufuta,Yamada Sci. Foundation, Osaka, Japan,(1999) p.153-155
    46. Investigation of DNA complexes with iron ions in solution Kasyanenko N., Arikainen N., Frisman E. /Biophysical Chemistry. 1998. Т. 70. № 2. С. 93-100.
    47. Study of the DNA packing caused by charged compounds of different nature in solution. Kasyanenko N.A., Zanina A.V., Plotnikova L.V., Simonenkov A.A., Defrenne S., Nazarova O.V., Panarin E.F./Macromolecular Symposia. 1998. Т. 136. С. 25-31
    48. Interaction of DNA with coordination compounds of bivalent platinum. III. platinum compounds with two pyrimidine ligands Kas’yanenko N.A., Nikolenko O.V., Prokhorova S.A., Frisman E.V., D’yachenko S.A., Smorygo N.A., Ivin B.A. Molecular Biology. 1997. Т. 31. № 2. С. 240-244.
    49. Interaction of DNA with coordination-compounds of divalent platinum 1. Effect of cis-diaminodichloroplatinum on DNA molecular-parameters in solution. Kasyanenko N.A., Valueva S.V., Smorygo N.A., D’yachenko S.A., Frisman E.V. Молекулярная биология. 1995. Т. 29. Вып. 2.С. 200-203
    50.  Interaction of DNA with coordination-compounds of bivalent platinum. 2. Effect of ligands localized in first coordination sphere. Kasyanenko N.A., Karymov M.A., D’yachenko S.A., Smorygo N.A., Frisman E.V. Молекулярная биология. 1995. Т. 29. Вып С. 340-347
    51. Hydrodynamic and optical behaviour of DNA molecule in a solutions of large ionic strength frisman E.V., Kasyanenko N.A. Молекулярная биология. 1990. Том 24, вып. 2. С. 251-259.
    52. Investigation of the molecular mechanism of the interaction of DNA with divalent metal-ions. Kas’yanenko N.A., Dyakonova N.E., Frisman É.V. Molecular Biology. 1989. Т. 23.  Вып. 4  Стр.: 765-771.
    53. Effect of Mn-2+ and Mg-2+ ions on the conformation of the DNA molecule.  Kosyanenko N.A., Selman-Khusein Sosa G., Uverskii V.N., Frisman E.V. Молекулярная биология. 1987. Т. 21. С. 117 -122.
    54.  Influence of ionic-strength and pH of the medium on polymer flocculants conformatioN. Kasyanenko NA, Frisman EV, Klenin SI, Bykova YN, Kochetkova IS. Vysokomolekulyarnye soedineniya seriya A.1987. Том: 29  Выпуск: 6  Стр.: 1129-1135.
    55. Study of the molecular characteristics of polymer flocculants in solutions of varying ionic-strength. Kasyanenko NA, Semenova OY, Klenin SI, Bykova YN, Medvedev GP, Avetisyan PK, Frisman EV, vysokomolekulyarnye soedineniya.1985.  Seriya A. Том: 27  Выпуск: 5  Стр.: 1073-1078
    56. Study of influence of pH media on conformation of DNA molecule. Kas’yanenko N.A., Bartoshevich S.F., Frisman E.V. Molecular Biology. 1985. Т. 19. 1136-1142

  • Lectures:

    1. «Modern problems of biophysics» – Bachelor, 1st year (AMP), 4 year (Physics)
    2. «Introduction to Molecular Biophysics» – Bachelor’s 3 course (Physics)
    3. «Physical chemistry of polymers» – Bachelor’s, 4 year (AMP)
    4. «Hydrodynamic methods of research of biopolymers», bachelor, 4 year (AMP)
    5. «The conformation of biopolymers in solution» (Master’s program “Molecular Biophysics”)
    6. «Methods of study of biological macromolecules» (Master’s program “Molecular Biophysics”)
    7. «Fundamentals of physics of biological macromolecules» (Graduate, Experimental Physics)

    Scientific supervision:

    PhD thesis:

    1. «Investigation of the large ionic strength effect on DNA molecule conformation in solution and development of method of its covalent fixation on a solid surface». Karymov Mikhail (1997)
    2. «Study of DNA interaction with binuclear platinum coordination compounds in solution». Haya Enrikes Ervin Fernando, Peru (2002)
    3. «The structural changing of DNA molecule induced by metal ions and metal-organic compounds». Bogdanov Alexey A. (2004)
    4. «Impact of solvent composition and gamma irradiation on interaction of DNA with platinum coordination compounds». Kosmotynskaya Yu. V. (2006)
    5. «DNA condensation induced by polycations and multicharged ions in solution». Dribinsky Boris A. (2012)
    6. «Analysis of DNA conformation changing after complexation with coordination compounds of platinum group metal».  Morozova Elena V. (2012)
    7. «Creating and study of DNA stabilized luminescent silver clusters». Volkov Ivan L. (2014)
    8. «Development of ways of DNA fixation on different surfaces and study the properties of the formed structures». Sokolov Petr A. (2014)
    9. «The conformational change of the DNA molecule in the interaction with platinum coordination compounds and silver». Zhang Qiushi, the People’s Republic of China (2015)

    Mastes thesis (since 2011)

    1. Sokolov P «Fixation of DNA on a silicon surface of n-type. Electrical properties of Si/DNA/Au interface» (2011)
    2. Lysyakova L «The compaction of DNA in solution induced by polycations and photosensitive amphiphilic ligands» (2012)
    3. Puchkova S «The metallization of DNA in solution and on the surface» (2012)
    4. Reveguk Z «Study of the interaction of new oxalate complexes of palladium (II) with a DNA molecule in vitro»
    5. Belyh R «The interaction of DNA with ions and aluminum nanoparticles in solution» (2012)
    6. Bozhkova E «The study of the interaction of DNA with coordination compounds of iron with phenanthroline ligands» (2012)
    7. Borisova I «Complexes of macromolecular DNA with platinum coordination compounds containing amino acids» (2013)
    8. Titov E «DNA conformational transitions caused by its interaction with the light-sensitive surfactant in the solution» (2013)
    9.  Alekseev G «Study of DNA complexes with biologically active compounds in the solution» (2013)
    10. Warsawsky M «Properties of systems formed with the DNA molecule and reduced silver» (2014)
    11. Kozhenkov P «The complexation of DNA with ruthenium and cobalt coordination compounds» (2014)
    12. Fironov A «The study of the interaction of gold nanoparticles with polymers» (2014)
    13. Tolstyko E «DNA in solution and the metallization on a substrate using silver nanoparticles and silver compounds» (2015)
    14. Unksov I «Ways of delivery of small interfering RNA and DNA in the cell-based surfactant» (2016)

    Bachelor thesis (since 2011):

    1. Titov A «Influence of salt concentration on the spectral properties of silver and gold nanoparticles in aqueous solution» (2011)
    2. Titov E «Interaction of DNA with photoactive surfactant» (2011)
    3. Taranenko I «Study of the interaction of the new oxalate complex palladium (II) a DNA molecule in vitro» (2012)
    4. Samsonov N «The study of the interaction of aluminum nanoparticles with DNA» (2012)
    5. Fironov A «Surface plasmon resonance method and its application to the study of solutions of DNA ligands» (2012)
    6. Warsawsky M «The formation of silver nanoparticles and investigation of their interaction with polyions in solution and on surfaces» (2012)
    7. Kozhenkov P «Study of the effect of ruthenium on the conformation of DNA molecules in solution» (2012)
    8. Krohmalyuk R «The study of the interaction of teotropine with  DNA molecule in vitro» (2013)
    9. Vashukevich E «DNA Complexes with short peptides» (2014)
    10. Simanov G «Study of the formation of silver nanoparticles to DNA solutions containing surfactants» (2014)
    11. Tolstyko E «Formation and study of DNA structures containing nanoparticles» (2014)
    12. Polshkov V «Gene vectors containing nanoparticles» (2014)
    13. Unksov I «DNA conformational changes caused by interaction with light sensitive compounds» (2014)
    14. Boldyrev A «The interaction of short peptides KE and KEDW DNA» (2015)
    15. Dokshokova L «DNA interaction with platinum and silver compounds in solution» (2015)
    16. Ikonnikov E «The metallization of DNA in solution and on surfaces»  (2015)
    17. Pavlenova K «The interaction of DNA with the coordination compound of platinum with a complex ligand»  (2016)
    18. Tikhomirov R «The interaction of europium coordination compound with  DNA molecule in vitro» (2016)

    At present research is carried out:

    PhD students:

    • Michael Warsawsky (PhD student 3 years)
    • Ekaterina Morozova (PhD student 3 years)
    • Unksov Ivan (PhD student 1 years )

    Master students:

    • Michael Osolodkov
    • Dokshokova Lolita
    • Alexander Boldyrev
    • Christina Pevlenova
    • Tikhomirov Roman

  • A dissertation councils membership:

    • D 212.232.33 by speciality 02.00.06 – macromolecular compounds (physico-mathematical sciences);
    • D 212.232.10 by speciality 03.01.02 – biophysics (biological sciences)
    • D 212.232.28 by speciality  02.00.10 – bioorganic chemistry (chemical sciences)

    An academic councils membership:

    • Member of the Scientific Council of the Physical Faculty of St. Petersburg State University
    • Member of the Scientific Council of the St. Petersburg State University

    Member of the educational commissions:

    • Member of the Educational Committee of the Academic Council of St. Petersburg State University
    • Member of Educational-methodical commission of the Faculty of Physics

  • ResearcherID: M-8608-2013
    ScopusID: 6602085797
    ORCID: 0000-0003-3018-2063
    SPIN-код: 5746-6931