Гуртовенко Андрей Алексеевич


Должность: доцент

Степень: д.ф.-м.н.

Ученое звание: профессор РАН

e-mail: a.gurtovenko на biosimu.org
web: http://biosimu.org
тел. +7(812)328-56-01

  • Компьютерное моделирование биомолекулярных систем (биомембраны, генные векторы)

    Основные публикации:

    1. S. G. Falkovich, H. Martinez-Seara, A. M. Nesterenko, I. Vattulainen, and A. A. Gurtovenko, What Can We Learn about Cholesterol’s Transmembrane Distribution Based on Cholesterol-Induced Changes in Membrane Dipole Potential? Journal of Physical Chemistry Letters 7, 4585-4590 (2016).
    2. A. Yu. Kostritskii, D. A. Kondinskaia, A. M. Nesterenko, A. A. Gurtovenko, Adsorption of Synthetic Cationic Polymers on Model Phospholipid Membranes: Insight from Atomic-Scale Molecular Dynamics Simulations, Langmuir 32, 10402-10414 (2016).
    3. D. A. Kondinskaia, A. Yu. Kostritskii, A. M. Nesterenko, A. Yu. Antipina, A. A. Gurtovenko, Atomic-Scale Molecular Dynamics Simulations of DNA-Polycation Complexes: Two Distinct Binding Patterns, Journal of Physical Chemistry B 120, 6546-6554 (2016).
    4. A. Yu. Antipina, A. A. Gurtovenko, Molecular-Level Insight into the Interactions of DNA with Phospholipid Bilayers: Barriers and Triggers, RSC Advances 6, 36425-36432 (2016).
    5. A. Yu. Antipina, A. A. Gurtovenko, Molecular Mechanism of Calcium-Induced Adsorption of DNA on Zwitterionic Phospholipid Membranes, Journal of Physical Chemistry B 119, 6638 — 6645 (2015).
    6.  A. A. Gurtovenko, A. S. Lyulina, Electroporation of Asymmetric Phospholipid Membranes, Journal of Physical Chemistry B 118, 9909 — 9918 (2014).
    7. E. Heikkila, H. Martinez-Seara, A. A. Gurtovenko, I. Vattulainen, J. Akola, Atomistic Simulations of Anionic Au144(SR)60 Nanoparticles Interacting with Asymmetric Model Lipid Membranes, Biochimica et Biophysica Acta (BBA) — Biomembranes 1838, 2852 — 2860 (2014).
    8. E. Heikkila, H. Martinez-Seara, A. A. Gurtovenko, M. Javanainen, H. Hakkinen, I. Vattulainen, J. Akola, Cationic Au Nanoparticle Binding with Plasma Membrane-Like Lipid Bilayers: Potential Mechanism for Spontaneous Permeation to Cells Revealed by Atomistic Simulations, Journal of Physical Chemistry C 118, 11131 — 11141 (2014).
    9.  W. Zhao, A. A. Gurtovenko, I. Vattulainen, M. Karttunen, Cationic DMPC/DOTAP Lipid Bilayers: Atomistic Insight for Structure and Dynamics, Journal of Physical Chemistry B 116, 269 — 276 (2012).
    10. A. A. Gurtovenko, J. Anwar, I. Vattulainen, Defect-Mediated Trafficking across Cell Membranes: Insights from In Silico Modeling, Chemical Reviews 110, 6077 — 6103 (2010).
    11. A. A. Gurtovenko, J. Anwar, Interaction of Ethanol with Biological Membranes: The Formation of Non-Bilayer Structures within the Membrane Interior and their Significance, Journal of Physical Chemistry B 113, 1983 — 1992 (2009).
    12. A. A. Gurtovenko, I. Vattulainen, Intrinsic Potential of Cell Membranes: Opposite Effects of Lipid Transmembrane Asymmetry and Asymmetric Salt Ion Distribution, Journal of Physical Chemistry B 113, 7194 — 7198 (2009).
    13. A. A. Gurtovenko, O. I. Onike, J. Anwar, Chemically-Induced Phospholipid Translocation Across Biological Membranes, Langmuir 24, 9656 — 9660 (2008).
    14. A. A. Gurtovenko, I. Vattulainen, Membrane Potential and Electrostatics of Phospholipid Bilayers with Asymmetric Transmembrane Distribution of Anionic Lipids, Journal of Physical Chemistry B 112, 4629 — 4634 (2008).
    15. A. A. Gurtovenko, I. Vattulainen, Effect of NaCl and KCl on Phosphatidylcholine and Phosphatidylethanolamine Lipid Membranes: Insight from Atomic-Scale Simulations for Understanding Salt-Induced Effects in the Plasma Membrane, Journal of Physical Chemistry B 112, 1953-1962 (2008).
    16. A. A. Gurtovenko, I. Vattulainen, The Molecular Mechanism of Lipid Flip-Flops, Journal of Physical Chemistry B 111, 13554 — 13559 (2007).
    17. A. A. Gurtovenko, J. Anwar, Modulating the Structure and Properties of Cell Membranes: The Molecular Mechanism of Action of Dimethyl Sulfoxide, Journal of Physical Chemistry B 111, 10453 — 10460 (2007).
    18. A. A. Gurtovenko, J. Anwar, Ion Transport through Chemically-Induced Pores in Protein-Free Phospholipid Membranes, Journal of Physical Chemistry B 111, 13379 — 13382 (2007).
    19. A. A. Gurtovenko, I. Vattulainen, Lipid Transmembrane Asymmetry and Intrinsic Membrane Potential: Two Sides of the Same Coin, Journal of the American Chemical Society 129, 5358 — 5359 (2007).
    20. A. A. Gurtovenko, I. Vattulainen, Ion Leakage Through Transient Water Pores In Protein-Free Lipid Membranes Driven by Transmembrane Ionic Charge Imbalance, Biophysical Journal 92, 1878 — 1890 (2007).
    21. A. A. Gurtovenko, I. Vattulainen, Pore Formation Coupled to Ion Transport through Lipid Membranes as Induced by Transmembrane Ionic Charge Imbalance: Atomistic Molecular Dynamics Study, Journal of the American Chemical Society 127, 17570 — 17571 (2005).
    22. A. A. Gurtovenko, Asymmetry of Lipid Bilayers Induced by Monovalent Salt: Atomistic Molecular Dynamics Study, Journal of Chemical Physics 122, 244902 (2005).
    23. A. A. Gurtovenko, M. Patra, M. Karttunen, and I. Vattulainen, Cationic DMPC/DMTAP Lipid Bilayers: Molecular Dynamics Study, Biophysical Journal 86, 3461 — 3472 (2004).

  • Курсы лекций:

    «Компьютерное моделирование биомолекулярных систем» (магистерская программа «Нанобиофизика», ПМФ)

    Руководство кандидатскими, магистерскими и бакалаврскими работами:

    Кандидатские  диссертации:

    1. «Computer modeling of the adsorption of DNA on a lipid bilayer consisting of the phosphatidylcholine molecules.» Antipina A (2017)

    Магистерские диссертации (с 2011 г.):

    1. «Computer simulation of the natural polysaccharide of arabinogalactan in dilute aqueous solution.» Sergeev D (2013)
    2. «Computer modeling of the DNA complexes with water-soluble polycations.» Kondinskaya D (2016)
    3. «The adsorption of cationic polymers on the surface of bacterial membranes. Computer Modelling.» Kostritsky A (2016)

    Бакалаврские работы (с 2011 г.):

    1. «Computer modeling of non-viral delivery vectors based on polyethyleneimine.» Kostritsky A (2014)
    2. «Computer modeling of the cationic polymer is polylysine.» Kondinskaya D (2014)

    В настоящее время научные исследования проводят :

    • PhD work. «Computer modeling of nucleic acid delivery systems based on cationic polymers,» Kondinskaya D (post-graduate student of the 1st year of study).
    • PhD work. «Interaction of biocompatible materials based on cellulose with model biological membranes. Computer simulation » Kostritsky A (post-graduate student of the 1st year of study).
    • Bachelor work. «Computer modeling of polypeptide chains aggregation processes» Lushpinskaya I
    • Bachelor work. «Computer simulation model phospholipid membranes,» Muhamadyarov E

  • Член диссертационного совета:

    • Д 212.232.40 (СПбГУ)

  • ResearcherID: J-6085-2013
    ScopusID: 6701662779
    ORCID: 0000-0002-9834-1617
    SPIN-код: 1092-8808

Опубликовано в